Additional cancer-specific nutrition guidelines recommend that supplements should not be used by cancer survivors for cancer prevention. Furthermore, the use of dietary supplements is not associated with any improvement in the overall survival of cancer patients. Supplement use for cancer prevention has not been shown to improve outcomes. Despite this high prevalence of use among cancer survivors, the joint World Cancer Research Fund (WCRF)/American Institute for Cancer Research (AICR) diet and exercise recommendations for cancer prevention state that “dietary supplements should not be used for cancer prevention”. Among cancer survivors, dietary supplement use is even more prevalent, with NHANES 2003–2016 data indicating a 70% use among this population. adults using at least one dietary supplement. We observed a high prevalence of dietary supplement use among breast cancer survivors and the potential for adverse interactions between the prescribed endocrine therapy and dietary supplements was common.ĭietary supplements-defined by the Dietary Supplement Health and Education Act of 1994 as herbal preparations, vitamins, and minerals-are commonly used, with 51% of U.S. Among the 353 women taking tamoxifen or AIs, 38% were taking dietary supplements with a potential risk of interactions. A total of 108 different types of dietary supplements were reported and 36 potential adverse interactions with tamoxifen or AIs were identified. Among 475 breast cancer survivors (2.9 (mean) or 2.5 (standard deviation) years from diagnosis), 393 (83%) reported using dietary supplements. The potential interactions with tamoxifen and AIs were identified using the Natural Medicine Database. This analysis examined the prevalence of self-reported dietary supplement use and the potential interactions with tamoxifen and aromatase inhibitors (AIs) among breast cancer survivors enrolled in three randomized controlled trials of lifestyle interventions conducted between 20. Several dietary supplements have potential pharmacokinetic and pharmacodynamic interactions that may change their clinical efficacy or potentiate adverse effects of the adjuvant endocrine therapy prescribed for breast cancer treatment. The World Cancer Research Fund/American Institute for Cancer Research specifies that dietary supplements should not be used for cancer prevention. The use of dietary supplements is common in the general population and even more prevalent among cancer survivors.
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